Medication -related adverse events in older people with dementia:causes and possible solutions

摘要: This submission for a PhD by previously published work is based upon six publications in peer reviewed journals, reflecting 9-year research programme. My has shown, coherent and original way, the difficulty treating people with dementia safe effective medication whilst providing research-founded guidance to develop mechanisms optimise choice minimise iatrogenic events. A wide range of methods, including systematic reviews, meta-analysis, randomised controlled trials (RCTs), quantitative mixed methods were used generate data, which supported exploration three themes. The first theme, understand incidence causes errors services, identified that may be more susceptible medication-related disease partly due inherent disease-related characteristics. One particular area concern use anti-psychotics treat Behavioural Psychological Symptoms Dementia (BPSD). second third themes, respectively, investigated novel pharmacological health services intervention limit anti-psychotic usage. phase found glutamate receptor blocker memantine showed some promise, further was clearly required. usage higher than official figures suggest review linking primary secondary care can such been widely cited, substantial contribution field, terms our understanding of, possible solutions limit, adverse events dementia. More importantly, this already informed clinical practice, patients, carers policy makers its demonstrable impact on policy. In my key lines enquiry future development own personal programme reduce risk associated vulnerable population.