Genomic Discovery Reveals a Molecular System for Resistance to Oxidative and Endoplasmic Reticulum Stress in Cultured Glioma
作者： Hassan M. Fathallah-Shaykh
DOI: 10.1001/ARCHNEUR.62.2.233
关键词: Apoptosis 、 DNA damage 、 Reactive oxygen species 、 Endoplasmic reticulum 、 Biology 、 Oxidative phosphorylation 、 Cell culture 、 Cell biology 、 Cancer cell 、 Pathology 、 Oxidative stress
摘要: Oxygen is required for respiration and the energetic processes that enable aerobic life. Reactive oxygen species free radicals, by-products of use, cause DNA damage induce endoplasmic reticulum (ER) stress apoptosis. However, rapidly multiplying cancer cells are resistant to ER oxidative stress-induced The present article reports results highly specific genome-scale expression discovery used identify genes differentially expressed in cultured glioma vs normal brain tissue. discovered states reveal a cohesive molecular system protects growing from
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