Genomic approaches to clinical drug resistance.

摘要: Detailed genomic studies related to drug resistance mechanisms are now possible because of the available information on human genome. The rapid advances in methodologies, such as microarray analysis for gene expression profiling, and even larger choice ofmethods developed scoring genetic variations among populations, will have a profound impact way we understand health disease. phenotype tumors is serious setback that limits usage chemotherapeutic agents treating cancers. Drug may arise due one several mechanisms, including altered metabolism, efflux, or decreased uptake. Until recently, our understanding secondary cellular regulators/factors contribute was limited lack appropriate analytical tools. Microarray polymorphism led identification characterization metabolic pathways intimately linked resistance. We summarize some recent areas polymorphisms their relevance disease general mechanisms’ particular. Lastly, introduce basic premise underlying emerging area metabonomics how it relevant