Maternal di-(2-ethylhexyl) phthalate exposure during pregnancy causes fetal growth restriction in a stage-specific but gender-independent manner.
作者： Ru Shen , Ling-Li Zhao , Zhen Yu , Cheng Zhang , Yuan-Hua Chen
DOI: 10.1016/J.REPROTOX.2016.12.003
关键词: Pregnancy 、 Intrauterine growth restriction 、 Anogenital distance 、 Internal medicine 、 Fetus 、 Gestational age 、 Phthalate 、 Developmental toxicity 、 Endocrinology 、 Gestation 、 Medicine
摘要: Di (2-ethylhexyl) phthalate (DEHP) is male developmental toxicant that impairs testis development with reduced anogenital distance. The present study aimed to investigate whether maternal DEHP exposure during pregnancy causes intrauterine growth restriction (IUGR) in a gender-specific manner and identify the critical window of DEHP-induced fetal IUGR. Pregnant mice were administered (0, 50 or 200mg/kg) by gavage. Fetal IUGR was observed not only males but also females when litters exposed on gestational day (GD)0-GD17. Interestingly, weight crown-rump length reduced, markedly dams GD13-GD17, slightly GD7-GD12, GD0-GD6. Further analysis showed GD7-GD12 inhibited cell proliferation, lowered placental weight, blood sinusoid area labyrinth layer. These results suggest induces stage-specific gender-independent manner.
sci-hub.se 参考文章(48)
Yi-Xin Wang, Ling You, Qiang Zeng, Yang Sun, Yue-Hui Huang, Cheng Wang, Peng Wang, Wen-Cheng Cao, Pan Yang, Yu-Feng Li, Wen-Qing Lu, Phthalate exposure and human semen quality: Results from an infertility clinic in China. Environmental Research. ,vol. 142, pp. 1- 9 ,(2015) , 10.1016/J.ENVRES.2015.06.010
Maribel Casas, Damaskini Valvi, Ana Ballesteros-Gomez, Mireia Gascon, Mariana F. Fernández, Raquel Garcia-Esteban, Carmen Iñiguez, David Martínez, Mario Murcia, Nuria Monfort, Noelia Luque, Soledad Rubio, Rosa Ventura, Jordi Sunyer, Martine Vrijheid, Exposure to Bisphenol A and Phthalates during Pregnancy and Ultrasound Measures of Fetal Growth in the INMA-Sabadell Cohort. Environmental Health Perspectives. ,vol. 124, pp. 521- 528 ,(2015) , 10.1289/EHP.1409190
Yongan Wang, Wei Liu, Qing Yang, Mingxi Yu, Zhou Zhang, Di (2-ethylhexyl) phthalate exposure during pregnancy disturbs temporal sex determination regulation in mice offspring Toxicology. ,vol. 336, pp. 10- 16 ,(2015) , 10.1016/J.TOX.2015.07.009
Christina M. Scifres, D. Michael Nelson, Intrauterine growth restriction, human placental development and trophoblast cell death The Journal of Physiology. ,vol. 587, pp. 3453- 3458 ,(2009) , 10.1113/JPHYSIOL.2009.173252
Tessa L. Crume, Ann Scherzinger, Elizabeth Stamm, Robert McDuffie, Kimberly J. Bischoff, Richard F. Hamman, Dana Dabelea, The long-term impact of intrauterine growth restriction in a diverse U.S. cohort of children: the EPOCH study. Obesity. ,vol. 22, pp. 608- 615 ,(2014) , 10.1002/OBY.20565
Jonatan Axelsson, Lars Rylander, Anna Rignell-Hydbom, Bo A.G. Jönsson, Christian H. Lindh, Aleksander Giwercman, Phthalate exposure and reproductive parameters in young men from the general Swedish population. Environment International. ,vol. 85, pp. 54- 60 ,(2015) , 10.1016/J.ENVINT.2015.07.005
Xi Chen, Qing-hong Zhou, Ling Leng, Xu Chen, Zeng-rong Sun, Nai-jun Tang, Effects of di(n-butyl) and monobutyl phthalate on steroidogenesis pathways in the murine Leydig tumor cell line MLTC-1. Environmental Toxicology and Pharmacology. ,vol. 36, pp. 332- 338 ,(2013) , 10.1016/J.ETAP.2013.04.013
J.H.W. Veerbeek, P.G.J. Nikkels, H.L. Torrance, J. Gravesteijn, E.D. Post Uiterweer, J.B. Derks, S.V. Koenen, G.H.A. Visser, B.B. Van Rijn, A. Franx, Placental pathology in early intrauterine growth restriction associated with maternal hypertension Placenta. ,vol. 35, pp. 696- 701 ,(2014) , 10.1016/J.PLACENTA.2014.06.375
Konstantin Svechnikov, Irina Svechnikova, Olle Söder, Inhibitory effects of mono-ethylhexyl phthalate on steroidogenesis in immature and adult rat Leydig cells in vitro Reproductive Toxicology. ,vol. 25, pp. 485- 490 ,(2008) , 10.1016/J.REPROTOX.2008.05.057
Roni W. Kobrosly, Sarah Evans, Amir Miodovnik, Emily S. Barrett, Sally W. Thurston, Antonia M. Calafat, Shanna H. Swan, Prenatal Phthalate Exposures and Neurobehavioral Development Scores in Boys and Girls at 6–10 Years of Age Environmental Health Perspectives. ,vol. 122, pp. 521- 528 ,(2014) , 10.1289/EHP.1307063