Neuroprotection of bradykinin/bradykinin B2 receptor system in cerebral ischemia.
作者： Bingyuan Ji , Baohua Cheng , Yanyou Pan , Chunmei Wang , Jing Chen
DOI: 10.1016/J.BIOPHA.2017.08.042
关键词: Signal transduction 、 Neurogenesis 、 Blood pressure 、 Internal medicine 、 Review article 、 Inflammation 、 Neuroprotection 、 Ischemia 、 Pharmacology 、 Endocrinology 、 Medicine 、 Bradykinin
摘要: Bradykinin B2 receptor (B2R) activated by its endogenous ligand bradykinin participates in various physiological processes including neurogenesis, neuronal differentiation, and control of inflammation blood pressure. Besides these effects, B2R has been demonstrated to protect neurons from ischemia/reperfusion (I/R) injury. Here, we highlight the mechanisms BK/B2R-mediated neuroprotective effects peripheral central nervous systems. Moreover, this review article summarizes some signaling pathways cerebral ischemia, leading a better understanding neuroprotection.
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