Dopamine Receptors in the Central Nervous System
作者： Ian Creese , A. Leslie Morrow , Stuart E. Leff , David R. Sibley , Mark W. Hamblin
DOI: 10.1016/S0074-7742(08)60627-3
关键词: Neurotransmitter 、 Central nervous system 、 Premovement neuronal activity 、 Biology 、 Prolactin 、 Receptor 、 Dopamine 、 Neuroscience 、 Neurochemical 、 Dopamine receptor
摘要: Publisher Summary Dopamine (DA) is an important central nervous system (CNS) pituitary modulator of prolactin, β -endorphin, and α -MSH secretion. This chapter discusses DA receptors, the pharmacological characteristics anatomical localizations several distinct DA-receptor subtypes delineated through radioligand binding biochemical studies, functions these actions dopaminergic agonists antagonists. Although, receptors are thought to function in CNS, there a great deal yet be understood regarding their biochemical, physiological, behavioral roles. Radioligand-binding studies have proved very useful determining mechanisms involved regulation alteration neuronal activity; however, future investigations may exploit this technique for study neurochemical plasticity. Regulation neurotransmitter hormone-receptor should examined during aging process, because if receptor progressively disturbed, it amenable therapy.
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