Do actinic keratoses and superficial squamous cell carcinomas have a specific immunoprofile

摘要: The link between actinic keratosis (AK), squamous cell carcinoma (SCC), and a fully functional immune system has been frequently observed but is poorly understood. Elderly immunosuppressed individuals those with weakened systems caused by disease are all at increased risk of developing AK and/or SCC. This particularly enhanced sites that receive high levels ultraviolet exposure from the sun, which thought to be driver DNA mutations in skin. appears play key role preventing these progressing malignant disease. often considered pre-cancerous lesion may develop into However, vast majority AKs, contrast SCCs, regress naturally or response immune-modifying medications. cellular mechanisms involved this immune-based process remain elusive raise following question: does make-up functionality within differ fundamentally SCC? chapter will outline skin as site considerable immunological activity, highlight consequences dysregulated activity skin, discuss what little we know infiltrates their associated functions