A second generation of centrally acting antihypertensive agents act on putative I1-imidazoline receptors
作者： Paul R. Ernsberger , Kelly L. Westbrooks , Odile M. Christen , Siegfried G. Schäfer
DOI: 10.1097/00005344-199220004-00002
关键词: Medulla 、 Adrenergic receptor 、 Rilmenidine 、 Chemistry 、 Moxonidine 、 Efaroxan 、 Pharmacology 、 Imidazoline receptor 、 Clonidine 、 Receptor
摘要: Both the hypotension and sedation elicited by centrally acting antihypertensive agents traditionally are ascribed to activation of α 2 -adrenergic receptors. However, second-generation such as moxonidine rilmenidine less sedating but retain efficacy. The vasodepressor action clonidine within its brainstem site in ventrolateral medulla has been linked a novel receptor that recognizes imidazoles related compounds
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