Origin and Properties of the Electrocardiogram T-Wave
DOI:
关键词: Ion channel 、 Ventricular action potential 、 Repolarization 、 Cell model 、 Nuclear magnetic resonance 、 Electrocardiogram T wave 、 Materials science 、 Ventricle 、 Cardiology 、 Ventricular myocytes 、 Internal medicine
摘要: The ventricle exhibits gradients in repolarization time both transmural and apicobasal directions. These gradients, caused by the varying strengths of cellular ionic currents different regions, affect morphology electrocardiographic T wave. Abnormal observed clinically alterations ECG, can increase susceptibility to arrhythmias, therefore characteristics as well their roles manifesting wave must be understood. UCLA rabbit ventricular action potential model is based on experimental data from myocytes along with reported ion channel properties. To recreate ventricle, were made conduction repolarizing currents, IKr Ito,f single cell simulate APDs in-situ. resulting cells then incorporated into a 3D model. Simulations performed presence direction an in-silico ECG was calculated. It found that transmurally, APD epi shorter than endo apicobasally, base apex give correct ECG.
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