Neural substrates underlying stimulation-enhanced motor skill learning after stroke.

摘要: Motor skill learning is one of the key components motor function recovery after stroke, especially driven by neurorehabilitation. Transcranial direct current stimulation can enhance neurorehabilitation and in stroke patients. However, neural mechanisms underlying retention stimulation-enhanced involving a paretic upper limb have not been resolved. These substrates were explored means functional magnetic resonance imaging. Nineteen chronic hemiparetic patients participated double-blind, cross-over randomized, sham-controlled experiment with two series. Each series consisted sessions: (i) an intervention session during which dual transcranial or sham was applied limb; (ii) imaging 1 week later, performed learned skill. The task, called 'circuit game', involves speed/accuracy trade-off consists moving pointer controlled computer mouse along complex circuit as quickly accurately possible. Relative to series, bilaterally over primary cortex resulted enhanced online learning; 1-week retention; (iii) superior transfer performance improvement untrained task. retention's enhancement associated trend towards normalization brain activation pattern relative A similar observed simple, task without constraint, despite lack behavioural difference between Finally, first continued This lasting more efficient recruitment network, that is, focused on motor-premotor areas damaged hemisphere, dorsal premotor cortex. Dual prolonged shaping activation, supported enhancements