Four analogues of spiroleptosphol isolated from Leptosphaeria doliolum
作者： Takanori Murakami , Taro Tsushima , Noboru Takada , Kazuaki Tanaka , Ken-ichi Nihei
DOI: 10.1016/J.BMC.2008.12.004
关键词: Lactone 、 Stereochemistry 、 Undecane 、 Chemistry 、 Proton NMR 、 Hemiacetal 、 Decarboxylation 、 Nuclear magnetic resonance spectroscopy 、 Leptosphaeria 、 Carbon-13 NMR
摘要: Spiroleptosphol B (2), spiroleptosphol C (3), norleptosphol (4) and hydroleptosphol (5) were isolated from ascomycete Leptosphaeria doliolum. Detailed (1)H (13)C NMR spectral analyses revealed these structural analogues of (1) which we have recently the same fungi. (2) carried an unprecedent 5,3-dioxatricyclo[4.4.0.1(1.4)]undecane framework in place spirobicyclo ring system 1. (3) was a 17-(R)-hydroxy derivative Norleptosphol deduced to be monocyclic structure biosynthetically resulted by decarboxylation 3. Although 5 gave broaden spectrum, it gradually transformed 2 suggested being hydrolysate
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