The role of microRNAs in synaptic plasticity, major affective disorders and suicidal behavior

摘要: Abstract Major affective disorders are common widespread conditions associated with multiple psychosocial impairments and suicidal risk in the general population. At least 3–4% of all depressive individuals die by suicide. a molecular level, behavior recently disturbances structural synaptic plasticity. A recent hypothesis suggested that small non-coding RNAs (ncRNAs), particular microRNAs (miRNAs), play critical role translational regulation at synapse. We performed selective overview current literature on miRNAs putative subcellular localization sites action mature neurons analyzing their neurogenesis, plasticity, pathological stress changes, major behavior. have played fundamental evolution brain functions. The perturbation some intracellular mechanisms as well impaired assembly, localization, specific RNA binding proteins may affect learning memory, presumably contributing to pathogenesis perhaps Also, miRNA dys-regulation has also been linked several neuropsychiatric diseases. However, further evidence needed order directly clarify