Genetic polymorphism in the manganese superoxide dismutase gene, antioxidant intake, and breast cancer risk: results from the Shanghai Breast Cancer Study
作者： Qiuyin Cai , Xiao-Ou Shu , Wanqing Wen , Jia-Rong Cheng , Qi Dai
DOI: 10.1186/BCR929
关键词: Biology 、 Oxidative stress 、 Breast cancer 、 Reactive oxygen species 、 Biochemistry 、 Carcinogenesis 、 Mitochondrion 、 Superoxide dismutase 、 Cancer research 、 Antioxidant 、 Mitochondrial DNA
摘要: Introduction It has been suggested that oxidative stress and mitochondrial DNA damage play important roles in breast cancer carcinogenesis. Manganese superoxide dismutase (MnSOD) is a major enzyme responsible for the detoxification of reactive oxygen species mitochondria. A T → C substitution MnSOD gene results Val Ala change at -9 position targeting sequence (Val-9Ala), which alters protein secondary structure thus affects transport into
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