Self-replication of complementary nucleotide-based oligomers

摘要: The development of non-enzymatic self-replicating systems based on autocatalytic template-directed reactions is a current objective bioorganic chemistry. Typically, self-complementary template molecule AB synthesized autocatalytically from two complementary fragments A and B. Natural replication nucleic acids, however, utilizes rather than strands. Here we report minimal implementation this type cross-catalytic syntheses hexadeoxynucleotide derivatives amino-trideoxynucleotides. In our experiments, templates compete for their combinatorial synthesis four common trimeric precursors. We provide kinetic evidence that self-replication can proceed with an efficiency similar to templates. observe selective stimulation synthesis, thus information transfer, seeding the reaction mixtures one chemically labelled bearing sequence products. Our results bring stage closer schemes might explain how replicating acids arose prebiotic Earth.