Prognostic significance of Ki67 proliferation index, HIF1 alpha index and microvascular density in patients with non-small cell lung cancer brain metastases

摘要: Survival upon diagnosis of brain metastases (BM) in patients with non-small cell lung cancer (NSCLC) is highly variable and established prognostic scores do not include tissue-based parameters. Patients who underwent neurosurgical resection as first-line therapy for newly diagnosed NSCLC BM were included. Microvascular density (MVD), Ki67 tumor proliferation index hypoxia-inducible factor 1 alpha (HIF-1 alpha) determined by immunohistochemistry. NSCLC BM specimens from 230 (151 male, 79 female; median age 56 years; 199 nonsquamous histology) 53/230 (23.0 %) matched primary samples available. Adjuvant whole-brain radiation (WBRT) was given to 153/230 (66.5 %) after resection. MVD HIF-1 indices significantly higher than tumors. In treated adjuvant WBRT, low expression associated favorable overall survival (OS), while among did correlate OS. Low diagnosis-specific graded assessment score (DS-GPA), index, high MVD, administration WBRT independently Incorporation parameters into the commonly used DS-GPA allowed refined discrimination subgroups. have promising value should be validated further studies.