2D Inorganic-Antimalarial Drug-Polymer Hybrid with pH-Responsive Solubility.
作者： Ji-Yeong Kim , Jae-Hun Yang , Ji-Hee Lee , Goeun Choi , Dae-Hwan Park
关键词: Zinc 、 Bioavailability 、 Salt (chemistry) 、 Solubility 、 Inorganic chemistry 、 Selectivity 、 Pharmaceutical formulation 、 Chemistry 、 Pharmacokinetics 、 Polymer
摘要: Artesunic acid (ASH), an antimalarial drug, has low oral bioavailability due to its aqueous solubility. To overcome this problem, artesunate (AS) was intercalated into zinc basic salt (ZBS) via co-precipitation. AS immobilized with a tilted double layer arrangement, which also confirmed by XRD and 1-D electron density mapping. In order decrease the release rate of under gastrointestinal conditions simultaneously increase intestinal conditions, ZBS-AS coated EUDRAGIT L100 (ZBS-AS-L100). Finally, we performed in-vivo pharmacokinetic study compare ZBS-AS-L100 that ASH. Surprisingly, it found former is 5.5 times greater than latter enhanced solubility thanks ternary hybridization ZBS L100. Therefore, present system great potential as novel drug formulation pH selectivity bioavailability.
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