Cell division cycle-associated 7-like gene: A novel biomarker for adverse survival in human high-grade gliomas

摘要: Background: High-grade primary gliomas are aggressively growing and have an unfavorable prognosis. The utility of prognostic biomarkers outcome in glioma patients is important for medical practice. Cell division cycle-associated 7-like (CDCA7L) protein modifies cancer progression metastasis. Nevertheless, its character defining the clinical prognosis human has not been illuminated. Subjects Methods: hypothesis this study was that CDCA7L upregulated gliomas. We studied two de-linked data from Gene Expression Omnibus (GEO) profile. first dataset (GDS1816/225081_s_at/CDCA7L) high-grade included age, gender, survival time. Another (GDS1962/225081_s_at/CDCA7L) also encompassed to estimate gene expression each pathological grading. Search Tool Retrieval Interacting Genes/Proteins (STRING) used survey protein-protein interaction (PPI) network CDCA7L-regulated oncogenesis. Results: Statistical analysis GEO profile revealed World Health Organization (WHO) Grade IV (n = 81) had higher mRNA level than II 7, P 2.15 × 10 −14) nontumor controls 23, 2.87 − 18). Kaplan-Meier reported with high levels 49) adverse those low 28). PPI oncogenesis showed as a potential hub protein. Conclusions: positive correlation WHO grading shorter survival. This finding suggests may be biomarker