Feed-Forward and Feed-Backward Amplification Model from Cochlear Cytoarchitecture: An Interspecies Comparison

摘要: The high sensitivity and wide bandwidth of mammalian hearing are thought to derive from an active process involving the somatic hair-bundle motility thousands outer hair cells uniquely found in cochleae. To better understand this, a biophysical three-dimensional cochlear fluid model was developed for gerbil, chinchilla, cat, human, featuring “push-pull” amplifier mechanism based on cytoarchitecture organ Corti using time-averaged Lagrangian method. Cochlear responses simulated compared with in vivo physiological measurements basilar membrane (BM) velocity, VBM, frequency tuning BM vibration, Q10 values representing sharpness curves. VBM simulation results gerbil chinchilla consistent cochlea measurements. Simulated mechanical curves maintaining constant value agree neural-tuning threshold better than those displacement value, which implies that inner more sensitive displacement. curve well neurons across species, appear be related part width membrane.