Dysregulation of Androgen Secretion and Steroid Metabolism in Polycystic Ovary Syndrome

作者: Robert L. Rosenfield

DOI: 10.1007/978-1-4613-8483-0_6

关键词: Steroid MetabolismAndrogen secretionFollicular atresiaCongenital adrenal hyperplasiaPolycystic ovaryOvarian HyperandrogenismInternal medicineLuteinizing hormone levelEndocrinologyLuteinizing hormoneMedicine

摘要: We have proposed that the essence of polycystic ovary syndrome (PCOS) is functional ovarian hyperandrogenism (FOH) (Fig. 6.1) (1, 2). Our model proposes FOH initiated by any disorder causes a large increase in intraovarian androgens. This leads to hyperandrogenemia, which responsible for pilosebaceous manifestations syndrome. also promotes process follicular atresia, anovulatory symptoms.

参考文章(30)
Randall B. Barnes, Robert L. Rosenfield, Stephen Burstein, David A. Ehrmann, Pituitary-Ovarian Responses to Nafarelin Testing in the Polycystic Ovary Syndrome New England Journal of Medicine. ,vol. 320, pp. 559- 565 ,(1989) , 10.1056/NEJM198903023200904
Andrew Rodin, Hansa Thakkar, Norman Taylor, Richard Clayton, Hyperandrogenism in polycystic ovary syndrome. Evidence of dysregulation of 11 beta-hydroxysteroid dehydrogenase. The New England Journal of Medicine. ,vol. 330, pp. 460- 465 ,(1994) , 10.1056/NEJM199402173300703
Hyperandrogenism in polycystic ovary syndrome. The New England Journal of Medicine. ,vol. 331, pp. 131- ,(1994) , 10.1056/NEJM199407143310216
Didier Dewailly, Marie-Christine Vantyghem, Christine Lemaire, Françoise Dufosse, André Racadot, Pierre Fossati, Screening heterozygotes for 21-hydroxylase deficiency among hirsute women: lack of utility of the adrenocorticotropin hormone test. Fertility and Sterility. ,vol. 50, pp. 228- 232 ,(1988) , 10.1016/S0015-0282(16)60064-X
Edward E. Wallach, Robert L. Barbieri, Samuel Smith, Kenneth J. Ryan, The role of hyperinsulinemia in the pathogenesis of ovarian hyperandrogenism Fertility and Sterility. ,vol. 50, pp. 197- 212 ,(1988) , 10.1016/S0015-0282(16)60060-2
STEPHEN FRANKS, DAVINIA M. WHITE, Prevalence of and Etiological Factors in Polycystic Ovarian Syndrome Annals of the New York Academy of Sciences. ,vol. 687, pp. 112- 114 ,(1993) , 10.1111/J.1749-6632.1993.TB43859.X
R L Rosenfield, R B Barnes, D A Ehrmann, Studies of the nature of 17-hydroxyprogesterone hyperresonsiveness to gonadotropin-releasing hormone agonist challenge in functional ovarian hyperandrogenism. The Journal of Clinical Endocrinology and Metabolism. ,vol. 79, pp. 1686- 1692 ,(1994) , 10.1210/JCEM.79.6.7989476
RICARDO AZZIZ, GRETCHEN WELLS, HOWARD A. ZACUR, RONALD T. ACTON, Abnormalities of 21-hydroxylase gene ratio and adrenal steroidogenesis in hyperandrogenic women with an exaggerated 17-hydroxyprogesterone response to acute adrenal stimulation. The Journal of Clinical Endocrinology and Metabolism. ,vol. 73, pp. 1327- 1331 ,(1991) , 10.1210/JCEM-73-6-1327
ROBERT L. ROSENFIELD, JAMES HELKE, ANNE W. LUCKY, Dexamethasone preparation does not alter corticoid and androgen responses to adrenocorticotropin. The Journal of Clinical Endocrinology and Metabolism. ,vol. 60, pp. 585- 589 ,(1985) , 10.1210/JCEM-60-3-585
Yilmaz Şahin, Fahrettin Keleştimur, 17-Hydroxyprogesterone response to buserelin testing in the polycystic ovary syndrome. Clinical Endocrinology. ,vol. 39, pp. 151- 155 ,(1993) , 10.1111/J.1365-2265.1993.TB01767.X