Microtubule-targeting anticancer agents from marine natural substance.

作者: Zhiguo Liu , Pengfei Xu , Tao Wu , Wenbin Zeng

DOI: 10.2174/187152061403140207163402

关键词: DrugNatural substanceDrug discoveryBiologyPharmacologyBiochemistry

摘要: Effective novel therapeutics is urgently needed due to increasing incidence of malignant cancer and drug multi-resistance. Natural products their derivatives have historically been a source pharmaceutical leads therapeutic drugs. Microtubuletargeting compounds are among the most promising candidates in combat against cancer. In particular, marine natural products (MNPs) demonstrated exceptional potency potential as anticancer agents. Drug discovery from MNPs provides new pathway to develop original this review, seven classes typical with diverse structures summarized. Bioactive marine compounds isolated different organisms including invertebrate animals, algae, fungi bacteria also discussed.

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