C/EBP Homologous Protein (CHOP) Activates Macrophages and Promotes Liver Fibrosis in Schistosoma japonicum-Infected Mice.

摘要: CCAAT/enhancer-binding homologous protein (CHOP), a transcriptional regulator induced by endoplasmic reticulum stress (ER stress) is pivotal factor in the ER stress-mediated apoptosis pathway. Previous studies have shown that CHOP involved formation of fibrosis variety tissues and associated with alternative macrophage activation. The role pathologic effects liver schistosomiasis has not been reported, underlying mechanisms remain unclear. This study aimed at understanding effect on Schistosoma japonicum (S. japonicum) vivo clarifying its mechanism. C57BL/6 mice were infected cercariae S. through abdominal skin. was examined. level IL-13 observed. expressions CHOP, Kruppel-like 4 (KLF4), signal transducer activator transcription 6 (STAT6), phosphorylation STAT6, interleukin-13 receptor alpha 1 (IL-13Rα1), interleukin-4 (IL-4Rα) analysed. eosinophilic granuloma collagen deposition found around eggs for 10 weeks. plasma IL-13Rα1 IL-4Rα tissue significantly increased. phosphorylated STAT6 enhanced while (KLF4) decreased tissue. expression colocalization CD206 Overall, these results suggest plays critical hepatic japonicum, likely promoting activation macrophages.