A clinico-pathological and immunological study of unfavourable non-Hodgkin lymphomas. Comparison of the Rappaport and Kiel classifications.

摘要: To evaluate the prognostic information of Kiel classification a homogeneous material 63 non-Hodgkin lymphomas unfavourable Rappaport histology were re-evaluated according to definitions classification. The patients selected from prospective lymphoma study including 775 patients. Only ambiguous histological diagnoses analysed independently by two hematopathologists accepted. Immunological markers tumours studied both in suspensions and on cryostate sections addition 40 Forty-one per cent (26/63) high grade malignancy classification, 59% (36/63) low-grade malignancy. DLPD group was most heterogeneous while better concordance found between DM CB/CC DH CB cases. However, subgroups classifications only partly equivalent. A good correlation high-grade malignant poorest prognosis (DU, DH). Eighty-eight B cell, 5% T cell 7% non-B-non-T phenotypes. Both morphologic predicted survival this material. Patients with phenotypes survived longer than non-B type. Among diffuse lymphomas, those nodular irregular distribution immunoglobulin C3d receptors tended respond longer. No obtained isotypes, or Fc-gamma receptors. It is concluded that equally reliable for clinical judgement as system immunological marker studies may add information.