Effects of Treatment Intensification on Acute Local Toxicity During Radiotherapy for Head and Neck Cancer: Prospective Observational Study Validating CTCAE, Version 3.0, Scoring System

摘要: Purpose To quantify the incidence and severity of acute local toxicity in head neck cancer patients treated with radiotherapy (RT), or without chemotherapy (CHT), using Common Terminology Criteria for Adverse Events, version 3.0 (CTCAE v3.0), scoring system. Methods Materials Between 2004 2006, 149 RT at our center were prospectively evaluated during treatment. On a weekly basis, monitored eight items recorded according to CTCAE v3.0 Of patients, 48 (32%) alone (conventional fractionation), 82 (55%) concomitant CHT conventional fractionation RT, 20 (13%) accelerated-fractionation CHT. Results Severe (Grade 3-4) adverse events 28% (mucositis), 33% (dysphagia), 40% (pain), 12% (skin) patients. Multivariate analysis showed be most relevant factor independently predicting worse (mucositis, dysphagia, weight loss, salivary changes). In contrast, previous surgery, acceleration older age, female gender, younger respectively, predicted outcome mucositis, pain, dermatitis. The T-score method confirmed that is “low-burden” class (T-score = 0.6) suggests concurrent “high-burden” 1.15). Combined had highest 1.9. Conclusions proved reliable tool various treatment intensities. effect on burden was clinically relevant.