The therapeutic value of poly(ethylene glycol)-modified proteins
作者： Mary L. Nucci , Robert Shorr , Abraham Abuchowski
DOI: 10.1016/0169-409X(91)90037-D
关键词: Immunogenicity 、 Clinical value 、 Recombinant DNA 、 NHL - Non-Hodgkin's lymphoma 、 Ethylene glycol 、 Poly ethylene glycol 、 Human proteins 、 Immune system 、 Biochemistry 、 Chemistry
摘要: … The discovery that the modification of proteins with poly(ethylene glycol) (PEGNOLOGY SM ) results in an adduct with decreased to non-existent immunogenicity increased circulating …
elsevier.com
sci-hub.se 参考文章(108)
Abuchowski A, Davis Ff, Davis S, Immunosuppressive properties and circulating life of Achromobacter glutaminase-asparaginase covalently attached to polyethylene glycol in man. Cancer treatment reports. ,vol. 65, pp. 1077- ,(1981)
Kaelyn Hadley, Paul Sato, Catalytic activity of administered gulonolactone oxidase polyethylene glycol conjugates. Enzyme. ,vol. 42, pp. 225- 234 ,(1989) , 10.1159/000469036
Davis Ff, Abuchowski A, Pyatak Ps, Preparation of a polyethylene glycol: superoxide dismutase adduct, and an examination of its blood circulation life and anti-inflammatory activity. Research communications in chemical pathology and pharmacology. ,vol. 29, pp. 113- ,(1980)
H Jr Berger, SV Pizzo, Preparation of polyethylene glycol-tissue plasminogen activator adducts that retain functional activity: characteristics and behavior in three animal species Blood. ,vol. 71, pp. 1641- 1647 ,(1988) , 10.1182/BLOOD.V71.6.1641.1641
David A. Cooney, Harry A. Milman, Marilyn R. Gaston, John P. Glynn, Arthur I. Goldberg, Elton R. Homan, The effects of immunization to L-asparaginase on antitumor and enzymatic activity. Cancer Research. ,vol. 33, pp. 256- 261 ,(1973)
K.J. Wieder, N.C. Palczuk, T. van Es, F.F. Davis, Some Properties of Polyethylene Glycol:Phenylalanine Ammonia-Lyase Adducts* Journal of Biological Chemistry. ,vol. 254, pp. 12579- 12587 ,(1979) , 10.1016/S0021-9258(19)86354-8
A Abuchowski, T van Es, N C Palczuk, F F Davis, Alteration of immunological properties of bovine serum albumin by covalent attachment of polyethylene glycol. Journal of Biological Chemistry. ,vol. 252, pp. 3578- 3581 ,(1977) , 10.1016/S0021-9258(17)40291-2
J S Beckman, R L Minor, C W White, J E Repine, G M Rosen, B A Freeman, Superoxide dismutase and catalase conjugated to polyethylene glycol increases endothelial enzyme activity and oxidant resistance. Journal of Biological Chemistry. ,vol. 263, pp. 6884- 6892 ,(1988) , 10.1016/S0021-9258(18)68727-7
Y K Park, F F Davis, A Abuchowski, S Davis, Alteration of the circulating life and antigenic properties of bovine adenosine deaminase in mice by attachment of polyethylene glycol. Clinical and Experimental Immunology. ,vol. 46, pp. 649- ,(1981)
D.Neil Granger, Gianfranco Rutili, Joe M. McCord, Superoxide radicals in feline intestinal ischemia Gastroenterology. ,vol. 81, pp. 22- 29 ,(1981) , 10.1016/0016-5085(81)90648-X