SDF-1 (CXCL12) is upregulated in the ischemic penumbra following stroke: association with bone marrow cell homing to injury.

摘要: The chemokine stromal-derived factor-1 (SDF-1, also known as CXCL12) and its receptor CXCR4 have been implicated in homing of stem cells to the bone marrow marrow-derived sites injury. Bone infiltrate brain give rise long-term resident following Therefore, SDF-1 expression patterns 40 mice were examined relative ischemic injury using a stroke model. Mice received transplants from green fluorescent protein (GFP) transgenic donors later underwent temporary middle cerebral artery suture occlusion (MCAo). was associated with blood vessels cellular profiles by 24 hours through at least 30 days post-MCAo. principally localized penumbra. majority reactive astrocytes; much this perivascular. GFP+ SDF-1-positive found neuropil regions increased immunoreactivity. Most vessel-associated resemble pericytes or perivascular microglia parenchyma displayed characteristics activated microglial cells. These findings suggest is important cells, especially monocytes, areas