Autoimmune channelopathies and related neurological disorders.

摘要: Ion channels are crucial elements in neuronal signaling and synaptic transmission, defects their function known to underlie rare genetic disorders, including some forms of epilepsy. A second class channelopathies, characterized by autoantibodies against ligand- voltage-gated ion channels, cause a variety peripheral neuromuscular ganglionic transmission. There is also emerging evidence for autoantibody-mediated mechanisms subgroups patients with central nervous system particularly those involving cognition or sleep often associated In all autoimmune the relationship between autoantibody specificity clinical phenotype complex. But this new information, channelopathies detected treated increasing success, future research promises insights into dysfunction at synapses determinants phenotype.