TMPRSS2-ERG Status in Circulating Tumor Cells as a Predictive Biomarker of Sensitivity in Castration-Resistant Prostate Cancer Patients Treated With Abiraterone Acetate
作者： Daniel C. Danila , Aseem Anand , Clifford C. Sung , Glenn Heller , Margaret A. Leversha
DOI: 10.1016/J.EURURO.2011.07.011
关键词: Abiraterone acetate 、 Circulating tumor cell 、 Oncology 、 Medicine 、 Internal medicine 、 PCA3 、 Prostate-specific antigen 、 TMPRSS2 、 Prostate cancer 、 Orchiectomy 、 Biomarker (medicine)
摘要: Background Abiraterone acetate (AA) is an androgen biosynthesis inhibitor shown to prolong life in patients with castration-resistant prostate cancer (CRPC) already treated chemotherapy. AA treatment results dramatic declines prostate-specific antigen (PSA) some and no others, suggesting the presence of molecular determinants sensitivity tumors.
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