Effect of chronic restraint stress and tianeptine on growth factors, growth-associated protein-43 and microtubule-associated protein 2 mRNA expression in the rat hippocampus
作者： Yasukazu Kuroda , Bruce S. McEwen
DOI: 10.1016/S0169-328X(98)00130-2
关键词: Endocrinology 、 Brain-derived neurotrophic factor 、 Neurotrophin-3 、 Neurotrophic factors 、 Hippocampus 、 Tianeptine 、 Chronic stress 、 Basic fibroblast growth factor 、 Neurotrophin 、 Biology 、 Internal medicine
摘要: Chronic restraint stress of rats for three weeks produces an atrophy apical dendrites in the CA3 region hippocampus. This alteration is blocked by novel antidepressant, tianeptine. In order to investigate underlying mechanism these phenomena, we evaluated effect chronic and tianeptine on mRNA expression neurotrophic factors such as brain-derived factor (BDNF), neurotrophin-3 (NT-3), basic fibroblast growth (bFGF). treatment did not change neurotrophins rat We also effects GAP-43 MAP2, both which are known be related development neurons. resulted a small decrease hippocampus, was prevented concomitant administration MAP2 changed either or treatment. conclude that neurotrophins, likely directly stress-induced dendritic prevention
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