Soluble transferrin receptors and iron deficiency, a step beyond ferritin. A systematic review.

摘要: UNLABELLED Iron deficiency is a common disorder; it can also be the first indicator of significant gastrointestinal pathology. Total iron stores are evaluated by ferritin measurement, but this often difficult, as coexistent disease obscure results. Bone marrow (BM) examination was previously felt to superior all known serological markers status, has number disadvantages. The validity measurement soluble transferrin receptors (sTfR) surrogate marker BM been subject various studies so far. AIM To critically review use sTfR for evaluation stores. METHODS A systematic computerised literature search, in order identify that compared against stain. RESULTS Twenty prospective were identified, which nine fulfilled inclusion criteria (sTfR anaemic adults alongside staining). For total 979 patients, different reference range used, levels 2.5 mg/L (29.5 nmol/L) consistently used threshold iron-deficiency anaemia resulting good specificity and sensitivity. CONCLUSION improves clinical diagnosis anaemia, especially presence coexisting chronic or malignancies. safety cost-effectiveness ferritin/sTfR-based approach exclude cancer proven with prospective, well standardised, multicentre trial meta-analysis.