Workshop Summary: Novel Aspects of the Functions of the TRAFs and cIAPs
作者： John Silke , Domagoj Vucic
DOI: 10.1007/978-1-4419-6612-4_6
关键词: Signal transduction 、 Ubiquitin ligase 、 Tumor necrosis factor alpha 、 Ubiquitin 、 Biology 、 Programmed cell death 、 Function (biology) 、 TRAF2 、 Plasma protein binding 、 Neuroscience
摘要: Session 8 of TNF2009 focused on the function RING containing proteins TRAF2 and cIAPs in TNF signaling. TNF-R1 signaling is understood to be carefully balanced between a pro-survival pro-apoptotic response and, as might expected for these E3 ligase domains, much data discussion revolved around regulation alternative pathways by ubiquitylation. The session was also notable talks that extended dramatically our understanding other such necrosis immune responses. Furthermore there thought provoking looking at role RIP kinase family they play non-apoptotic cell death initiated TNF.
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