N-Silylation of amines mediated by Et3SiH/KOtBu
作者： Fabrizio Palumbo , Simon Rohrbach , Tell Tuttle , John A. Murphy
关键词: Reagent 、 Dehydrogenation 、 Chemistry 、 Amine gas treating 、 Catalysis 、 Silylation 、 Aniline 、 Triethylsilane 、 Silane 、 Polymer chemistry
摘要: Silylation of primary and secondary amines is reported, using triethylsilane as the silylating reagent in presence potassium tert-butoxide (KOtBu). The reaction proceeds well 0.2 equiv KOtBu. In competition experiments, aniline selectively silylated over aliphatic amines. Computational studies support a catalytic mechanism which initiated by KOtBu interacting with silane to form KH amine. then takes role base propagation cyclic mechanism, deprotonates This reacts R3SiH afford product R3SiNR’R” regenerate KH.
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