C-linked heterocycloalkyl substituted pyrimidines and their uses
作者： Snahel Patel , Frederick Cohen
DOI:
关键词: Chemistry 、 Stereochemistry 、 Pyrimidine 、 Ring (chemistry) 、 Organic chemistry
摘要: The present invention provides for pyrimidine compounds of Formula (I-I) and embodiments thereof. In in which R1, R2, R3, R4, R5, R6' m, n the "het" ring are as described herein. Also provided pharmaceutical compositions comprising (I) methods using such compositions.
lens.org 参考文章(50)
David R. Brittelli, Peter A. Blomgren, Kevin S. Currie, Scott A. Mitchell, Amide derivatives as btk inhibitors in the treatment of allergic, autoimmune and inflammatory disorders as well as cancer ,(2009)
Steven L. Regen, Synthetic phosphatidyl cholines useful in forming liposomes ,(1982)
Ernest Ludwig Eliel, Samuel H. Wilen, Lewis N. Mander, Stereochemistry of Organic Compounds ,(1962)
Hans Bundgaard, Design of prodrugs Elsevier , Sole distributors for the USA and Canada, Elsevier Science Pub. Co.. ,(1985)
Implications of the Blood-Brain Barrier and Its Manipulation Springer US. ,(1989) , 10.1007/978-1-4613-0701-3
Michael Siu, Wen Liu, Guibai Liang, Anthony Estrada, Snahel Patel, Joseph P. Lyssikatos, Kevin Chen, Substituted pyrazoles and uses thereof ,(2014)
Bernard Malfroy-Camine, Method for increasing blood-brain barrier permeability by administering a bradykinin agonist of blood-brain barrier permeability ,(1990)
Howard C. Ansel, Loyd V. Allen, Nicholas G. Popovich, Ansel's Pharmaceutical Dosage Forms and Drug Delivery Systems ,(2004)
Takara Ino, Yoshinari Haruta, Takashi Tsuji, Hidetaka Fujihara, Hiroyuki Sugiyama, Pyridine Derivative and Medicinal Agent ,(2011)
Alfonso R. Gennaro, Remington: The Science and Practice of Pharmacy ,(2003)