Synthesis of some 1-(2-naphthyl)-2-(imidazole-1-yl)ethanone oxime and oxime ether derivatives and their anticonvulsant and antimicrobial activities.
作者： Arzu Karakurt , Sevim Dalkara , Meral Özalp , Süheyla Özbey , Engin Kendi
DOI: 10.1016/S0223-5234(01)01223-5
关键词: Imidazole 、 Antibacterial agent 、 Azole 、 Bicyclic molecule 、 Nafimidone 、 Chemistry 、 Antimicrobial 、 Oxime 、 Chemical synthesis 、 Organic chemistry
摘要: In this study, oxime and oxime ether derivatives of anticonvulsant nafimidone [1-(2-naphthyl)-2-(imidozole-1-yl)ethanone] were prepared as potential anticonvulsant compounds. …
elsevier.com
sci-hub.se 参考文章(12)
A Balsamo, B Macchia, Adriano Martinelli, Elisabetta Orlandini, A Rossello, F Macchia, G Brocalli, P Domiano, Synthesis and antimicrobial properties of substituted 3-aminoxy-(E)-2-methoxyiminopropionyl penicillins and cephalosporins European Journal of Medicinal Chemistry. ,vol. 25, pp. 227- 233 ,(1990) , 10.1016/0223-5234(90)90205-H
Jeffrey M. Liebman, Josef A. Schneider, Chapter 2. Anticonvulsant Agents Annual Reports in Medicinal Chemistry. ,vol. 20, pp. 11- 20 ,(1985) , 10.1016/S0065-7743(08)61028-3
Keith A. M. Walker, Marshall B. Wallach, Donald R. Hirschfeld, 1-(Naphthylalkyl)-1H-imidazole derivatives, a new class of anticonvulsant agents. Journal of Medicinal Chemistry. ,vol. 24, pp. 67- 74 ,(1981) , 10.1021/JM00133A015
Giovanni Grassi, Francesco Foti, Francesco Risitano, Giuseppe Bruno, Francesco Nicolo, Giovanni De Munno, Reaction of N-unsubstituted imidazoles with benzonitrile oxide Journal of the Chemical Society, Perkin Transactions 1. pp. 2615- 2619 ,(1993) , 10.1039/P19930002615
David W. Robertson, Joseph H. Krushinski, E. E. Beedle, J. David Leander, David T. Wong, R. C. Rathbun, Structure-activity relationships of (arylalkyl)imidazole anticonvulsants: comparison of the (fluorenylalkyl)imidazoles with nafimidone and denzimol. Journal of Medicinal Chemistry. ,vol. 29, pp. 1577- 1586 ,(1986) , 10.1021/JM00159A004
Dante Nardi, Alberto Tajana, Amedeo Leonardi, Renzo Pennini, Ferruccio Portioli, Maria Jose Magistretti, Alessandro Subissi, Synthesis and anticonvulsant activity of N-(benzoylalkyl)imidazoles and N-(.omega.-phenyl-.omega.-hydroxyalkyl)imidazoles Journal of Medicinal Chemistry. ,vol. 24, pp. 727- 731 ,(1981) , 10.1021/JM00138A017
Ünsal Çaliş, Sevim Dalkara, Mevlüt Ertan, Rümeysa Sunal, The significance of the imidazole ring in anticonvulsant activity of (arylalkyl)imidazoles. Archiv Der Pharmazie. ,vol. 321, pp. 841- 846 ,(1988) , 10.1002/ARDP.19883211203
Wolfgang Löscher, Dieter Schmidt, Strategies in antiepileptic drug development: is rational drug design superior to random screening and structural variation? Epilepsy Research. ,vol. 17, pp. 95- 134 ,(1994) , 10.1016/0920-1211(94)90012-4
M.J. Eadie, Anticonvulsant drugs. An update. Drugs. ,vol. 27, pp. 328- 363 ,(1984) , 10.2165/00003495-198427040-00003
E. Kendi, S. Özbey, A. Karakurt, S. Dalkara, 2‐(Imidazol‐1‐yl)‐1‐(2‐naphthyl)ethanone Oxime Acta Crystallographica Section C-crystal Structure Communications. ,vol. 54, pp. 1513- 1515 ,(1998) , 10.1107/S0108270198005071