Intrinsic Penicillin Resistance in Enterococci
作者： ROBERTA FONTANA , MARCO LIGOZZI , FABRIZIA PITTALUGA , GIUSEPPE SATTA
关键词: Genetics 、 Amp resistance 、 Microbiology 、 Overproduction 、 Penicillin 、 Point mutation 、 Enterococcus faecalis 、 Bacteria 、 Enterococcus faecium 、 Enterococcus hirae 、 Biology
摘要: ABSTRACT Penicillin resistance development in enterococci has been associated with overproduction of a low-affinity penicillin-binding protein (PBP) that is normal component the PBP pattern these bacteria and apparently able to substitute functions other PBPs. In resistant mutants Enterococcus hirae ATCC 9790 (PBP5) was deletion genetic element, located 1 kb upstream pbp5 gene, which negatively controlled PBP5 synthesis. Hypersusceptibility penicillin point mutation causes premature termination translation. Structural homologies between PBPs different enterococcal species have suggested by cross-reactivity antibodies raised against E. faecium faecalis. Acquisition high-level ampicillin over-production PBP5, which, compared PBP5...
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