High Degree of Dilated Virchow-Robin Spaces on MRI is Associated with Increased Risk of Dementia

摘要: The clinical significance of dilated Virchow-Robin spaces (dVRS) remains unclear and their impact on cognitive performances has only been reported in small sample studies. Our aim was to assess the association between severity dVRS risk incident dementia decline an elderly cohort. degree both white matter basal ganglia were ranked using high-resolution 3D MRI a population-based 1,778 non-demented participants from 65 80 years age, who had cerebral at baseline. Cognitive function assessed diagnosed during 4-year follow-up period. Cox proportional hazard models used examine four-level score dementia. relat ionship change cognition examined linear mixed effect models. During 6,135 person-years follow-up, 27 individuals developed highest associated with strong increase independently other standard factors dementia, for (HR = 9.8, 95% CI 1.7-55.3) 5.8, 1.2-28.4). After further adjustment hyperintensity volume brain infarcts, this remained signific ant matter. Higher rate found be related high but not These results need confirmation they suggest tha t assessment may help identify groups that are increased