Changes in monoaminergic neuronal function in the lower brain stem following subarachnoid hemorrhage induced in rats
作者： Katsutoshi Hirata , Teruaki Kawano , Kazuo Mori
DOI: 10.1007/BF00711563
关键词: Endocrinology 、 Internal medicine 、 Monoaminergic 、 Monoamine neurotransmitter 、 Microdialysis 、 Serotonergic 、 Anesthesia 、 Pargyline 、 Solitary nucleus 、 Homovanillic acid 、 Medicine 、 Vasospasm
摘要: 1. We investigated the function of monoaminergic neurons in lower brain stem following subarachnoid hemorrhage (SAH) induced rats, by measuring monoamine metabolites, usingin vivo microdialysis techniques. 2. A dialysis probe was implanted nucleus tractus solitarius (NTS) and perfusates were assayed high-performance liquid chromatography (HPLC) with electrochemical detection (ECD). 3. The main metabolites measured NTS extracellular space 3,4-dihydroxyphenyl acetic acid (DOPAC), homovanillic (HVA) 5-hydroxyindoleacetic (5-HIAA). 4. Monoamine rat nonspecifically increased, at least acute phase after cisternal injection blood or saline. 5. The disappearance rates 5-HIAA decline early DOPAC pargyline administration (75 mg/kg, i.p.) most rapid 2 days induction SAH, then recovered gradually. 6. These results suggest that functions noradrenergic serotonergic may be disturbed predominantly case vasospasm rats.
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sci-hub.se 参考文章(29)
RICHARD L. KLEIN, A LARGE SECOND POOL OF NOREPINEPHRINE IN THE HIGHLY PURIFIED VESICLE FRACTION FROM BOVINE SPLENIC NERVE Frontiers in Catecholamine Research#R##N#Proceedings of the Third International Catecholamine Symposium Held at the University of Strasbourg, Strasbourg, France May 20–25, 1973. pp. 423- 425 ,(1973) , 10.1016/B978-0-08-017922-3.50077-0
Miklós Palkovits, László Záborszky, Neuroanatomy of central cardiovascular control. Nucleus tractus solitarii: afferent and efferent neuronal connections in relation to the baroreceptor reflex arc. Progress in Brain Research. ,vol. 47, pp. 9- 34 ,(1977) , 10.1016/S0079-6123(08)62709-0
A Imperato, G Di Chiara, Trans-striatal dialysis coupled to reverse phase high performance liquid chromatography with electrochemical detection: a new method for the study of the in vivo release of endogenous dopamine and metabolites The Journal of Neuroscience. ,vol. 4, pp. 966- 977 ,(1984) , 10.1523/JNEUROSCI.04-04-00966.1984
T J Delgado, J Brismar, N A Svendgaard, Subarachnoid haemorrhage in the rat: angiography and fluorescence microscopy of the major cerebral arteries. Stroke. ,vol. 16, pp. 595- 602 ,(1985) , 10.1161/01.STR.16.4.595
Kurt Racké, Erich Muscholl, Release of Endogenous 3,4‐Dihydroxyphenylethylamine and Its Metabolites from the Isolated Neurointermediate Lobe of the Rat Pituitary Gland. Effects of Electrical Stimulation and of Inhibition of Monoamine Oxidase and Reuptake Journal of Neurochemistry. ,vol. 46, pp. 745- 752 ,(1986) , 10.1111/J.1471-4159.1986.TB13035.X
A.B. Loach, C.R. Benedict, Plasma catecholamine concentrations associated with cerebral vasospasm Journal of the Neurological Sciences. ,vol. 45, pp. 261- 271 ,(1980) , 10.1016/0022-510X(80)90170-7
M.-F. Suaud-Chagny, R. Steinberg, C. Mermet, K. Biziere, F. Gonon, In vivo voltammetric monitoring of catecholamine metabolism in the A1 and A2 regions of the rat medulla oblongata. Journal of Neurochemistry. ,vol. 47, pp. 1141- 1147 ,(2006) , 10.1111/J.1471-4159.1986.TB00732.X
Ramiro D. Lobato, Jesús Marín, Mercedes Salaices, Javier Burgos, Fernando Rivilla, Antonio G. García, Effect of experimental subarachnoid hemorrhage on the adrenergic innervation of cerebral arteries Journal of Neurosurgery. ,vol. 53, pp. 477- 479 ,(1980) , 10.3171/JNS.1980.53.4.0477
T Kawano, K Tsutsumi, H Miyake, K Mori, Striatal dopamine in acute cerebral ischemia of stroke-resistant rats. Stroke. ,vol. 19, pp. 1540- 1543 ,(1988) , 10.1161/01.STR.19.12.1540
Madhu Kalia, Kjell Fuxe, Menek Goldstein, Rat medulla oblongata. II. Dopaminergic, noradrenergic (A1 and A2) and adrenergic neurons, nerve fibers, and presumptive terminal processes The Journal of Comparative Neurology. ,vol. 233, pp. 308- 332 ,(1985) , 10.1002/CNE.902330303