Social consequences of ethanol: Impact of age, stress, and prior history of ethanol exposure

摘要: The adolescent period is associated with high significance of interactions peers, frequency stressful situations, and rates alcohol use. At least two desired effects that may contribute to heavy problematic drinking during adolescence are its abilities both facilitate peers alleviate anxiety, perhaps especially anxiety seen in social contexts. Ethanol-induced facilitation can be using a simple model the rat, normal adolescents, but not their more mature counterparts, demonstrating this ethanol-related facilitation. Prior repeated stress induces expression ethanol-induced adults further enhances socially facilitating ethanol among rats. In contrast, under circumstances, rats less sensitive than inhibition induced by higher doses insensitive anxiolytic ethanol. Sensitivity modified prior or exposure at ages. Shortly following restraint exposure, adolescents exhibit anxiety-like behavior, indexed reduced preference, enhanced sensitivity ethanol, through ethanol-associated reinstatement preference these adolescents. Repeated restraint, similar as well, eliciting behavior increasing acute ethanol; stressor also decreases inhibition. persisting consequences early differ from immediate consequences, males exposed adolescence, females those later showing when tested adulthood. Adult show whereas adult late demonstrate insensitivity suppressing To extent results applicable humans, live events make attractive for stressed due properties, therefore fostering levels drinking. Retention adolescent-typical responsiveness including inhibiting put risk development alcohol-related disorders life.