[18] Ribonucleotide reductase from Pyrococcus furiosus

摘要: Publisher Summary DNA synthesis depends on a balanced supply of the four deoxyribonucleotides. In all living organisms, with no exception to date, this is achieved by reduction corresponding ribonucleoside diphosphates, NDPs, or triphosphates, NTPs. This reaction catalyzed fascinating family allosterically regulated metalloenzymes, named ribonucleotide reductases (RNRs). It now generally accepted that life was first based RNA and emergence reductase key event allowed transition from world Instead, in contemporary metabolism, at least three distinct classes RNR are found, which probably products divergent evolution common ancestor. chapter deals enzyme P. furiosus as prototype for thermophilic RNRs. Some aspects, such allosteric regulation studied other RNRs, also discussed.