gyrA Mutations in Ciprofloxacin-Resistant Bartonella bacilliformis Strains Obtained In Vitro
作者： Michael F. Minnick , Zachary R. Wilson , Laura S. Smitherman , D. Scott Samuels
DOI: 10.1128/AAC.47.1.383-386.2003
关键词: Microbiology 、 Bartonella bacilliformis 、 Point mutation 、 Mutant 、 Ciprofloxacin 、 Escherichia coli 、 Biology 、 Fluoroquinolone Antibiotic 、 Bartonella 、 DNA gyrase
摘要: We isolated and characterized mutants of Bartonella bacilliformis that are resistant to the fluoroquinolone antibiotic ciprofloxacin, which targets A subunit DNA gyrase. Mutants had single point mutations in gyrA gene changed either Asp-90 Gly or Asp-95 Asn 3- 16-fold higher resistance, respectively, ciprofloxacin than did wild-type B. bacilliformis. is homologous Asp-87 Escherichia coli GyrA a common residue mutated fluoroquinolone-resistant strains other bacteria. This first report mutation at an homologue, corresponds Asp-82 E. GyrA.
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