Selective ganglionated plexi ablation for paroxysmal atrial fibrillation
作者： Evgeny Pokushalov , Alex Romanov , Pavel Shugayev , Sergey Artyomenko , Natalya Shirokova
DOI: 10.1016/J.HRTHM.2009.05.018
关键词: Ablation 、 Atrial fibrillation 、 Vagus nerve 、 Vagotomy 、 Heart septum 、 Internal medicine 、 Stimulation 、 Blood pressure 、 Medicine 、 Cardiology 、 Anesthesia 、 Catheter ablation
摘要: Background Selective ganglionated plexi (GP) ablation guided by high-frequency stimulation has been proposed for the treatment of paroxysmal atrial fibrillation (AF), but efficacy method is not established. Objective This study sought to compare selective GP identified with extensive regional targeting anatomic areas in patients AF. Methods Eighty AF (age 53 ± 9 years) were randomized undergo or left at sites GP. For (n = 40), targets where vagal reflexes evoked stimulation. Vagal defined as prolongation R-R interval >50% and a concomitant decrease blood pressure (>20 mm Hg) during The end point procedure was failure reproduce repeated ablation, lesions delivered clustering. Results At 13.1 1.9 months, 42.5% 77.5% free symptomatic (PAF) ( P .02). Parasympathetic denervation more prominent than compared these recurrence immediately after this trend abolished 6 months. Conclusion directed does eliminate majority patients. An approach confers better results.
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