Microchimerism

摘要: Recent studies indicate cells transfer between fetus and mother during pregnancy can persist in both decades later. The presence within one individual of a small population of from another genetically distinct individual is referred to as microchimerism. Naturally acquired microchimerism has recently been investigated autoimmune diseases, including scleroderma, thyroiditis, primary biliary cirrhosis, Sjogren syndrome, systemic lupus, dermatomyositis, and neonatal lupus. Iatrogenic chimerism been transplantation and following blood transfusion. Considering findings naturally acquired microchimerism along with iatrogenic suggests microchimerism can have detrimental and/or beneficial effects settings. identification of tissue-specific either or iatrogenic microchimerism (eg, cardiac myocytes) raises the possibility that be target autoimmunity alternatively contribute tissue repair. Advances this new frontier research varied numerous implications for human health are summarized.