Insulin-like effect of epidermal growth factor in isolated rat hepatocytes. Modulation of the alpha-1-adrenergic stimulation of ureagenesis.
作者： J.Adolfo García-Sáinz , M.Isabel Tussié-Luna , S.M.Teresa Hernández-Sotomayor
DOI: 10.1016/0167-4889(86)90113-8
关键词: Hepatocyte 、 Stimulation 、 Alpha (ethology) 、 Insulin 、 Phosphatidylinositol 、 Internal medicine 、 Endocrinology 、 Calcium 、 Epidermal growth factor 、 Adrenergic 、 Biology
摘要: Abstract Insulin and epidermal growth factor (EGF) inhibit the stimulation of ureagenesis induced by adrenaline ( α 1 -adrenergic effect) in hepatocytes from control rats incubated medium without calcium cells hypothyroid rats. In euthyroid normal buffer neither insulin or EGF diminished ureagenesis. No effect on phosphatidylinositol labeling was observed under any conditions. It is suggested that mimics action one pathways action: calcium-independent, insulin-sensitive pathway which predominates
elsevier.com
sci-hub.se 参考文章(29)
J A García-Sáinz, F Mendlovic, M A Martínez-Olmedo, Effects of phorbol esters on α1-adrenergic-mediated and glucagon-mediated actions in isolated rat hepatocytes Biochemical Journal. ,vol. 228, pp. 277- 280 ,(1985) , 10.1042/BJ2280277
G van de Werve, J Proietto, B Jeanrenaud, Control of glycogen phosphorylase interconversion by phorbol esters, diacylglycerols, Ca2+ and hormones in isolated rat hepatocytes. Biochemical Journal. ,vol. 231, pp. 511- 516 ,(1985) , 10.1042/BJ2310511
I. Diamond, A. Legg, J.A. Schneider, E. Rozengurt, Glycolysis in quiescent cultures of 3T3 cells. Stimulation by serum, epidermal growth factor, and insulin in intact cells and persistence of the stimulation after cell homogenization. Journal of Biological Chemistry. ,vol. 253, pp. 866- 871 ,(1978) , 10.1016/S0021-9258(17)38184-X
Silvia Corvera, S.M.Teresa Hernandez-Sotomayor, J.Adolfo Garcia-Sainz, Modulation by thyroid status of cyclic AMP-dependent and Ca2+-dependent mechanisms of hormone action in rat liver cells: Possible involvement of two different transduction mechanisms in α1-adrenergic action Biochimica et Biophysica Acta. ,vol. 803, pp. 95- 105 ,(1984) , 10.1016/0167-4889(84)90060-0
W H Moolenaar, R J Aerts, L G Tertoolen, S W de Laat, The epidermal growth factor-induced calcium signal in A431 cells Journal of Biological Chemistry. ,vol. 261, pp. 279- 284 ,(1986) , 10.1016/S0021-9258(17)42466-5
K R Schwarz, R M Graham, S Corvera, J A García-Sáinz, Phorbol esters inhibit alpha 1-adrenergic effects and decrease the affinity of liver cell alpha 1-adrenergic receptors for (-)-epinephrine. Journal of Biological Chemistry. ,vol. 261, pp. 520- 526 ,(1986) , 10.1016/S0021-9258(17)36122-7
S.M.Teresa Hernández-Sotomayor, J.Adolfo García-Sáinz, Adrenergic regulation of ureogenesis in hepatocytes from adrenalectomized rats: Possible involvement of two pathways of signal transduction in α1-adrenergic action FEBS Letters. ,vol. 166, pp. 385- 388 ,(1984) , 10.1016/0014-5793(84)80118-0
J P Dehaye, B P Hughes, P F Blackmore, J H Exton, Insulin inhibition of α-adrenergic actions in liver Biochemical Journal. ,vol. 194, pp. 949- 956 ,(1981) , 10.1042/BJ1940949
R H Cooper, K E Coll, J R Williamson, Differential effects of phorbol ester on phenylephrine and vasopressin-induced Ca2+ mobilization in isolated hepatocytes. Journal of Biological Chemistry. ,vol. 260, pp. 3281- 3288 ,(1985) , 10.1016/S0021-9258(19)83618-9
Choliparambil K. Pushpendran, Silvia Corvera, J.Adolfo García-Sáinz, Effect of insulin on alpha1-adrenergic actions in hepatocytes from euthyroid and hypothyroid rats Biochemical and Biophysical Research Communications. ,vol. 118, pp. 451- 459 ,(1984) , 10.1016/0006-291X(84)91324-X