The effects of paramagnetic contrast agents on metabolite protons in aqueous solution.
作者： Philip S Murphy , Martin O Leach , Ian J Rowland
DOI: 10.1088/0031-9155/47/6/401
关键词: Chemistry 、 Gadolinium 、 Nuclear magnetic resonance 、 Metabolite 、 Aqueous solution 、 Choline 、 Nuclear chemistry 、 DOTA 、 Paramagnetism 、 In vivo 、 Creatine
摘要: The longitudinal (R1) and transverse (R2) relaxivities of the clinically used contrast agents Gd(DTPA)2−, Gd(DOTA)− Gd(DTPA-BMA) have been determined in mixed aqueous metabolite solutions for choline, creatine N-acetylaspartate. Measurements were performed at 1.5 T using a STEAM sequence on 25 mM pH = 7.4 22 °C. data showed that all metabolites, R1 ~ R2. largest range relaxivity values was found where R2 6.8 ± 0.3 mM−1 s−1 choline 0.4 Variation attributed primarily to differences between charges paramagnetic agent metabolite. maximum potential influence vivo signals calculated measured relaxivities.
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