HLA-DR Antigens in HBsAg-Positive Chronic Active Liver Disease with and without Associated Delta Infection
作者： Barbara Forzani , Giovanni C. Actis , Giorgio Verme , Antonio Amoroso , Iolanda Borelli
关键词: Viral hepatitis 、 Liver disease 、 Human leukocyte antigen 、 Chronic liver disease 、 Hepatobiliary disease 、 Medicine 、 Immunology 、 Autoimmunity 、 Viral disease 、 HBsAg 、 Hepatology
摘要: The A, B, C and DR locus specificities of the human leukocyte antigens system (HLA) were determined in 45 delta-positive 44 delta-negative Italian patients, all with HBsAg-positive chronic active liver disease; controls 526 healthy blood donors matched for age, sex geographical origin. HLA-A, gene frequencies not significantly changed. In were: DR2, 37.8%; DR3, 20%; DR4, 11.1%. 13.6%; 36.4%; 0%. Control 19.4%; 17.1%; 18.5%. corrected p values differences between patients pc = 0.046; NS (not significant); NS. NS; 0.03; 0.002. These findings show that: (a) a genetic marker autoimmunity, might assist establishment HBsAg disease absence delta superinfection; (b) DR2 is linked failure to clear agent, (c) DR4 may protect from virus B persistence. Identification adventitious factors such as help uncover subgroup carriers who are genetically predisposed develop disease.
elsevier.com
sci-hub.se 参考文章(12)
M. Rizzetto, J. W. k. Shih, J. L. Gerin, The hepatitis B virus-associated delta antigen: isolation from liver, development of solid-phase radioimmunoassays for delta antigen and anti-delta and partial characterization of delta antigen. Journal of Immunology. ,vol. 125, pp. 318- 324 ,(1980)
M. Rizzetto, B. Hoyer, M. G. Canese, J. W. Shih, R. H. Purcell, J. L. Gerin, delta Agent: association of delta antigen with hepatitis B surface antigen and RNA in serum of delta-infected chimpanzees Proceedings of the National Academy of Sciences of the United States of America. ,vol. 77, pp. 6124- 6128 ,(1980) , 10.1073/PNAS.77.10.6124
A CARBONARA, W MAYR, M RIZZETTO, L CONTU, E. S CURTONI, M DEMARCHI, P FARCI, C LAVARINI, E OLIVETTI, Endemic HBV infection, tissue autoantibodies and HLA: Analysis of a Sardinian population Tissue Antigens. ,vol. 22, pp. 289- 294 ,(2008) , 10.1111/J.1399-0039.1983.TB01205.X
P. Rubinstein, B. Fedun, M. Witt, L.Z. Cooper, F. Ginserg-Fellner, The HLA system in congenital rubella (CR) patients with and without diabetes Human Immunology. ,vol. 5, pp. 168- ,(1982) , 10.1016/0198-8859(82)90109-4
Mario Rizzetto, GIORGIO VERME, SERAFINO RECCHIA, FERRUCCIO BONINO, PATRIZIA FARCI, SARINO ARICÒ, RENATA CALZIA, ANTONIO PICCIOTTO, MASSIMO COLOMBO, HANS POPPER, Chronic Hepatitis in Carriers of Hepatitis B Surface Antigen, with Intrahepatic Expression of the Delta Antigen: An Active and Progressive Disease Unresponsive to Immunosuppressive Treatment Annals of Internal Medicine. ,vol. 98, pp. 437- 441 ,(1983) , 10.7326/0003-4819-98-4-437
J.M. Ambinder, N. Chiorazzi, A. Gibofsky, M. Fotino, H.G. Kunkel, Special characteristics of cellular immune function in normal individuals of the HLA-DR3 type. Clinical Immunology and Immunopathology. ,vol. 23, pp. 269- 274 ,(1982) , 10.1016/0090-1229(82)90113-1
M.A. Pellegrino, S. Ferrone, M.P. Dierich, R.A. Reisfeld, Enhancement of sheep red blood cell human lymphocyte rosette formation by the sulfhydryl compound 2-amino ethylisothiouronium bromide Clinical Immunology and Immunopathology. ,vol. 3, pp. 324- 333 ,(1975) , 10.1016/0090-1229(75)90019-7
Ian R. Mackay, Immunological aspects of chronic active hepatitis. Hepatology. ,vol. 3, pp. 724- 728 ,(2007) , 10.1002/HEP.1840030517
Gary A. Levy, Francis V. Chisari, The immunopathogenesis of chronic HBV induced liver disease. Springer Seminars in Immunopathology. ,vol. 3, pp. 439- 459 ,(1981) , 10.1007/BF01951492
Cladd E. Stevens, Robert A. Neurath, R. Palmer Beasley, Wolf Szmuness, HBeAg and anti‐hbe detection by radioimmunoassay: Correlation with vertical transmission of hepatitis B virus in Taiwan Journal of Medical Virology. ,vol. 3, pp. 237- 241 ,(1979) , 10.1002/JMV.1890030310