Emerging Microtubule Targets in Glioma Therapy

摘要: Major advances in the genomics and epigenomics of diffuse gliomas glioblastoma to date have not been translated into effective therapy, necessitating pursuit alternative treatment approaches for these therapeutically challenging tumors. Current knowledge microtubules cancer development new microtubule-based strategies high-grade are topic this review article. Discussed cellular, molecular, pharmacologic aspects microtubule cytoskeleton underlying mitosis interactions with other cellular partners involved cell cycle progression, directional migration, tumor invasion. Special focus is placed on (1) aberrant overexpression βIII-tubulin, a survival factor associated hypoxic microenvironment dynamic instability microtubules; (2) ectopic γ-tubulin, which addition its conventional role as microtubule-nucleating protein has recently emerged transcription interacting oncogenes kinases; (3) microtubule-severing ATPase spastin emerging motility cells; (4) modulating posttranslational modifications tubulin context interaction motor proteins. Specific antineoplastic discussed include downregulation targeted molecules aimed at achieving sensitization effect currently used mainstay therapies. The potential classes tubulin-binding agents inhibitors also examined. Understanding molecular mechanisms underpinning distinct behaviors glioma tumorigenesis drug resistance key discovery novel targets that will fundamentally change prognostic outlook patients gliomas.