Facile synthesis of cucurbit[n]uril derivatives via direct functionalization: expanding utilization of cucurbit[n]uril

作者: Sang Yong Jon , Narayanan Selvapalam , Dong Hyun Oh , Jin-Koo Kang , Soo-Young Kim

DOI: 10.1021/JA036536C

关键词: SolubilityChemical stabilityCucurbiturilOrganic synthesisHildebrand solubility parameterStereochemistryPeptide drugChemistrySurface modification

摘要: A long-standing problem in cucurbituril chemistry is answered through the first direct functionalization of cucurbit[n]uril (CB[n]; n = 5-8)) leading to perhydroxyCB[n] which can be further modified provide tailored CB[n] derivatives with desired functional groups and good solubility. Anchoring a CB[6] derivative on surface its potential application as sensor are demonstrated. forms nanospheres possible use protein peptide drug delivery.

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