Bevacizumab and gefitinib enhanced whole-brain radiation therapy for brain metastases due to non-small-cell lung cancer.
作者： R.F. Yang , B. Yu , R.Q. Zhang , X.H. Wang , C. Li
DOI: 10.1590/1414-431X20176073
关键词: Bevacizumab 、 Response Evaluation Criteria in Solid Tumors 、 Gefitinib 、 Retrospective cohort study 、 Combined Modality Therapy 、 Internal medicine 、 Medicine 、 Lung cancer 、 Oncology 、 Carcinoma 、 Randomized controlled trial
摘要: Non-small-cell lung cancer (NSCLC) patients who experience brain metastases are usually associated with poor prognostic outcomes. This retrospective study proposed to assess whether bevacizumab or gefitinib can be used improve the effectiveness of whole radiotherapy (WBRT) in managing metastases. A total 218 NSCLC multiple were retrospectively included this and randomly allocated bevacizumab-gefitinib-WBRT group (n=76), gefitinib-WBRT (n=77) WBRT (n=75). Then, tumor responses evaluated every 2 months based on Response Evaluation Criteria Solid Tumors version 1.0. Karnofsky performance status neurologic examination documented 6 after treatment. Compared standard WBRT, could significantly enhance response rate (RR) disease control (DCR) (P<0.001). At same time, RR DCR received higher than those gefitinib-WBRT. The overall survival (OS) rates progression-free (PFS) also differed among (48.6 29.8%), (36.7 29.6%) (9.8 14.6%) groups (P<0.05). Although was slightly more toxic gefitinib-WBRT, toxicity tolerable. As suggested by prolonged PFS OS status, substantially improved efficacy management NSCLC.
bjournal.org
core.ac.uk 参考文章(40)
Patrick Therasse, Susan G Arbuck, Elizabeth A Eisenhauer, Jantien Wanders, Richard S Kaplan, Larry Rubinstein, Jaap Verweij, Martine Van Glabbeke, Allan T van Oosterom, Michaele C Christian, Steve G Gwyther, New guidelines to evaluate the response to treatment in solid tumors Bulletin Du Cancer. ,vol. 87, pp. 881- 886 ,(2000)
Jessica L. Hubbs, Jessamy A. Boyd, Donna Hollis, Junzo P. Chino, Mert Saynak, Chris R. Kelsey, Factors associated with the development of brain metastases: analysis of 975 patients with early stage nonsmall cell lung cancer Cancer. ,vol. 116, pp. 5038- 5046 ,(2010) , 10.1002/CNCR.25254
Eugènia Verger, Miguel Gil, Ricardo Yaya, Núria Viñolas, Salvador Villà, Teresa Pujol, Llorenç Quintó, Francesc Graus, Temozolomide and concomitant whole brain radiotherapy in patients with brain metastases: A phase II randomized trial International Journal of Radiation Oncology*Biology*Physics. ,vol. 61, pp. 185- 191 ,(2005) , 10.1016/J.IJROBP.2004.04.061
R. Berardi, E. Porfiri, M. Scartozzi, P. Lippe, R.R. Silva, D. Nacciarriti, E.T. Menichetti, D. Tummarello, F. Carle, A. Piga, R. Cellerino, Elderly patients with advanced non-small cell lung cancer. A pase II study with weekly cisplatin and gemcitabine. Oncology. ,vol. 65, pp. 198- 203 ,(2003) , 10.1159/000074471
Phillip Davey, David Hoegler, Marguerite Ennis, Jennifer Smith, A phase III study of accelerated versus conventional hypofractionated whole brain irradiation in patients of good performance status with brain metastases not suitable for surgical excision Radiotherapy and Oncology. ,vol. 88, pp. 173- 176 ,(2008) , 10.1016/J.RADONC.2008.05.020
Richard C Curry, Saurabh Dahiya, Vyshak Alva Venur, Jeffrey J Raizer, Manmeet S Ahluwalia, Bevacizumab in high-grade gliomas: past, present, and future. Expert Review of Anticancer Therapy. ,vol. 15, pp. 387- 397 ,(2015) , 10.1586/14737140.2015.1028376
B. Besse, S. F. Lasserre, P. Compton, J. Huang, S. Augustus, U.-P. Rohr, Bevacizumab Safety in Patients with Central Nervous System Metastases Clinical Cancer Research. ,vol. 16, pp. 269- 278 ,(2010) , 10.1158/1078-0432.CCR-09-2439
J.P. van Meerbeeck, D. Fennell, D. Lacombe, J. Welch, C. Gridelli, A.G. Pallis, L. Serfass, R. Dziadziuszko, Targeted therapies in the treatment of advanced/metastatic NSCLC European Journal of Cancer. ,vol. 45, pp. 2473- 2487 ,(2009) , 10.1016/J.EJCA.2009.06.005
Soo-Yeon Park, Young Kim, Hongryull Pyo, Gefitinib radiosensitizes non-small cell lung cancer cells through inhibition of ataxia telangiectasia mutated Molecular Cancer. ,vol. 9, pp. 222- 222 ,(2010) , 10.1186/1476-4598-9-222
Paul W. Sperduto, Brian Berkey, Laurie E. Gaspar, Minesh Mehta, Walter Curran, A New Prognostic Index and Comparison to Three Other Indices for Patients With Brain Metastases: An Analysis of 1,960 Patients in the RTOG Database International Journal of Radiation Oncology*Biology*Physics. ,vol. 70, pp. 510- 514 ,(2008) , 10.1016/J.IJROBP.2007.06.074