Colchicine-induced lesion of rat hippocampal granular cells prevents conditioned active avoidance with perforant path stimulation as conditioned stimulus, but not conditioned emotion

摘要: Abstract Successful acquisition of active avoidance by rats with low frequency (15 cps) stimulation the perforant path as a conditioning stimulus is correlated slowly developing long-term enhancement path-granular cell synapses. After selective destruction granular cells stimulated side unilateral microinjection 1.6 μg/0.2 μl colchicine into dentate area, field potentials could no longer be evoked test stimuli and animals subsequently failed to acquire conditioned CS. However, colchicine-treated showed same development emotional responses saline controls they also successfully light tone These results suggest that are necessarily involved in pathway for Other targets path, e.g., ipsi- contralateral CA1 pyramidal cells, or antidromic activation entorhinal cortex seem an insufficient substitute this avoidance, but would probably participate responses. The additionally support our hypothesis, post-conditioning LTP synapses contribute and/or storage memory trace.