The synthesis and characterization of glutathione-modified superparamagnetic iron oxide nanoparticles and their distribution in rat brains after injection in substantia nigra.
作者： Guihua Han , Baolin Zhang , Hao Zhang , Dong Han , Jie Tan
DOI: 10.1007/S10856-018-6209-3
关键词: Axoplasmic transport 、 Endocytosis 、 Nanoparticle 、 PEG ratio 、 Vesicle 、 Glutathione 、 Materials science 、 Polyethylene glycol 、 Biophysics 、 Substantia nigra
摘要: Glutathione-modified superparamagnetic iron oxide nanoparticles (GSH-SPIONs) were prepared by conjugating glutathione (GSH) on the surface of PEG (Polyethylene glycol)/PEI (polyethyleneimine)-SPIONs which synthesized thermal decomposition method. Thermogravimetric analysis showed that mass fraction GSH SPIONs was 30.64 wt%. GSH-SPIONs in PBS injected into substantia nigra rat brains. The subcellular distributions brains examined transmission electron microscope (TEM). A remarkable amount found vesicles inside cell bodies and axons, mitochondria. TEM pictures show enter neuronal cells endocytosis travel through axoplasmic transport. have great potential as drug delivery agents brain to treat diseases or study function via mitochondria-targeting way transport way.
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