p16 Tumor Suppressor
作者： Ken McCormack , Alexander Kamb
DOI: 10.1007/978-1-59259-230-2_8
关键词: Kinase activity 、 Kinase 、 Cell cycle 、 Cyclin-dependent kinase 、 Cell biology 、 Cell cycle checkpoint 、 Cyclin 、 Chemistry 、 Transition (genetics) 、 Suppressor
摘要: p16, a protein named for its migration rate on denaturing gels, is member of class functionally similar proteins called cyclin-dependent kinase inhibitors (CDKI). p16 and relatives bind to CDKs inhibit their activity. Because cyclins form the core cell cycle apparatus, positioned directly regulate some most basic decisions. In eukaryotic cells, typically described in terms four component phases: G1, S, G2, M. Most regulation occurs at G1—S G2—M transitions. higher eukaryotes, G1 checkpoint especially important. This precisely where acts, activity biochemically linked other regulators transition, including wellknown regulator (and tumor suppressor protein), Rb.
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